4 Comments
User's avatar
тна Return to thread
A Midwestern Doctor's avatar

Yup it's a very complicated subject.

Expand full comment
mejbcart's avatar

yes, it is. I look lot into dipole moments of macromolecules and gave a small intro in:

https://mejbcart.substack.com/p/sars-cov-2-spike-protein-5g-and-covid19

these are STATIC quantities, always connected to the 3D geometry of charge distribution inside of the entire object. It moves with it or changes when the shape is changing. For that post I calculated the Spike dipole moment and showed there that it is exactly directed toward the 3-meric axis of the complex which enters the cell membrane. It is like a needle punching the hole in the already hugely charged lipid bilayers of every normal cell.

The charges inside of the Spike are the key, in my opinion.

Expand full comment
A Midwestern Doctor's avatar

that is really interesting. I wonder if something that suited to the task could have formed naturally...

I also wonder how having focused linear areas of high charge densities affects zeta potential because in the past I've always looked at the cation being symetrical/spherical in its effect.

Out of curiosity, what is your background?

Expand full comment
mejbcart's avatar

This is strange, substack erased all my personal info... Under my newsletter there was always that info, but no more now., just wonder why??:

Anyway my fields are, or better, were..:

physics/biophysics, macromolecular crystallography with bioinformatics, synchrotron instumentation...

In regard to ionic shapes, look at the molecular orbitals, there are rarely spherical..

Expand full comment