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Yes, SSRIs DO work for some. I was bullied into Lexepro by a doctor, and took it just to prove to her that I didn't need it. After two days, I woke up a different person: happy, and most startling, guilt-free. I had felt guilty about everything, and would beat myself up for every mistake. Ten years later, I am still on the smallest dose, and I have zero side effects. I would love to go off, because who wants to admit they're on an anti-depressant? What I would like to see is a test that patients could take that could tell us which patients would actually benefit from SSRIs. MWD has mentioned a process called methylation, and a test, but has not given enough detail that I can take to my (newer and much better) doctor.

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Yes im interested in learning more about this too. I'm a rapid responder taking 20 mg prozac twice a week. I also take 50 mg amitriptyline hs twice a week. I've read the book doc recommended and need to read it again(i love to read and thought i had the book next to me to say the name but it's replaced with Think Like a Monk lol). Both of these meds have been life savers for me.

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